Upstream actuation for bluff-body wake control driven by a genetically inspired optimization

The control of bluff-body wakes for reduced drag and enhanced stability has traditionally relied on the so-called direct-wake control approach. By the use of actuators or passive devices, one can manipulate the aerodynamic loads that act on the rear of the model. An alternative approach for the manipulation of the flow is to move the position of the actuator upstream, hence interacting with an easier-to-manipulate boundary layer. The present paper comprises a bluff-body flow study via large-eddy simulations to investigate the effectiveness of an upstream actuator (positioned at the leading edge) with regard to the manipulation of the wake dynamics and its aerodynamic loads. A rectangular cylinder with rounded leading edges, equipped with actuators positioned at the front curvatures, is simulated at. A genetic algorithm (GA) optimization is performed to find an effective actuation that minimizes drag. It is shown that the GA selects superharmonic frequencies of the natural vortex shedding. Hence, the induced disturbances, penetrating downstream in the wake, significantly reduce drag and lateral instability. A comparison with a side-recirculation-suppression approach is also presented, the latter case being worse in terms of reduced drag (only 8 % drag reduction achieved), despite the total suppression of the side recirculation bubble. In contrast, the GA optimized case contributes to a 20 % drag reduction with respect to the unactuated case. In addition, the large drag reduction is associated with a reduced shedding motion and an improved lateral stability

Numerical investigation of the wake bi-stability behind a notchback Ahmed body

Large-eddy simulations are used to investigate the origin of the wake asymmetry and symmetry behind notchback Ahmed bodies. Two different effective backlight angles, beta(1) = 17.8 degrees and beta(2) = 21.0 degrees, are simulated resulting in wake asymmetry and symmetry in flows without external perturbations, in agreement with previous experimental observations. In particular, the asymmetric case presents a bi-stable nature showing, in a random fashion, two stable mirrored states characterized by a left or right asymmetry for long periods. A random switch and several attempts to switch between the bi-stability are observed. The asymmetry of the flow is ascribed to the asymmetric separations and reattachments in the wake. The deflection of the near-wall flow structures behind the slant counteracting the asymmetry drives the wake to be temporarily symmetric, triggering the switching process of the bi-stable wake. The consequence of deflection that forces the flow structure to form on the opposite side of the slant is the decisive factor for a successful switch. Modal analysis applying proper orthogonal decomposition is used for the exploration of the wake dynamics of the bi-stable nature observed

Suppression of vibration transmission in coupled systems with an inerter-based nonlinear joint

This study proposes an inerter-based nonlinear passive joint device and investigates its performance in suppression of vibration transmission in coupled systems. The joint device comprises an axial inerter and a pair of lateral inerters creating geometric nonlinearity, with the nonlinear inertance force being a function of the relative displacement, velocity, and acceleration of the two terminals. Both analytical approximations based on the harmonic balance method and numerical integration are used to obtain the steady-state response amplitude. Force transmissibility and time-averaged energy flow variables are used as performance indices to evaluate the vibration transmission in the coupled system, with subsystems representing the dominant modes of interactive engineering structures. The effects of adding the proposed joint to the force-excited subsystem or to the coupling interface of subsystems on suppression performance are examined. It is found that the insertion of the inerter-based nonlinear joint can shift and bend response peaks to lower frequencies, substantially reducing the vibration of the subsystems at prescribed frequencies. By adding the joint device, the level of vibration force and energy transmission between the subsystems can be attenuated in the range of excitation frequencies of interest. It is shown that the inerter-based nonlinear joint can be used to introduce an anti-peak in the response curve and achieve substantially lower levels of force transmission and a reduced amount of energy transmission between subsystems. This work provides an in-depth understanding of the effects of inerter-based nonlinear devices on vibration attenuation and benefits enhanced designs of coupled systems for better dynamic performance

Neoadjuvant SBRT combined with immunotherapy in NSCLC: from mechanisms to therapy

The utilisation of neoadjuvant immunotherapy has demonstrated promising preliminary clinical outcomes for early-stage resectable non-small-cell lung cancer (NSCLC). Nevertheless, it is imperative to develop novel neoadjuvant combination therapy regimens incorporating immunotherapy to further enhance the proportion of patients who derive benefit. Recent studies have revealed that stereotactic body radiotherapy (SBRT) not only induces direct tumour cell death but also stimulates local and systemic antitumour immune responses. Numerous clinical trials have incorporated SBRT into immunotherapy for advanced NSCLC, revealing that this combination therapy effectively inhibits local tumour growth while simultaneously activating systemic antitumour immune responses. Consequently, the integration of SBRT with neoadjuvant immunotherapy has emerged as a promising strategy for treating resectable NSCLC, as it can enhance the systemic immune response to eradicate micrometastases and recurrent foci post-resection. This review aims to elucidate the potential mechanism of combination of SBRT and immunotherapy followed by surgery and identify optimal clinical treatment strategies. Initially, we delineate the interplay between SBRT and the local tumour immune microenvironment, as well as the systemic antitumour immune response. We subsequently introduce the preclinical foundation and preliminary clinical trials of neoadjuvant SBRT combined with immunotherapy for treating resectable NSCLC. Finally, we discussed the optimal dosage, schedule, and biomarkers for neoadjuvant combination therapy in its clinical application. In conclusion, the elucidation of potential mechanism of neoadjuvant SBRT combined immunotherapy not only offers a theoretical basis for ongoing clinical trials but also contributes to determining the most efficacious therapy scheme for future clinical application

Transarterial chemoembolization with or without multikinase inhibitors for patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis of randomized controlled trials

BackgroundRandomized controlled trials (RCTs) testing the combination therapy of transarterial chemoembolization (TACE) plus multikinase inhibitor (MKI) in patients with unresectable hepatocellular carcinoma (HCC) have yielded inconsistent results.MethodsIn this work, a systematic review and meta-analysis was performed to compare the TACE+MKI combination therapy versus TACE monotherapy in HCC patients with time to progression (TTP) adopted as primary outcome.ResultsA total of 10 RCTs comprising 2837 patients receiving combination therapy (TACE plus sorafenib, brivanib, orantinib or apatinib) were included. TACE+MKI significantly prolonged TTP (hazard ratio [HR] 0.74, 95% CI 0.62-0.89, p=0.001) versus TACE monotherapy. Subgroup analysis suggested MKI administration before TACE might be preferable to post-TACE MKI for TTP. TACE+MKI also increased objective response rate (ORR) (risk ratio [RR] 1.17, 95% CI 1.03-1.32, p=0.01), but failed to improve overall survival (OS) (HR 0.98, 95% CI 0.86-1.13, p=0.82) and progression-free survival (PFS) (HR 0.75, 95% CI 0.50-1.12, p=0.16). The incidence of any adverse event (AE) did not significantly differ between TACE+MKI and TACE groups (RR 1.17, 95% CI 0.96-1.42, p=0.01), while serious AEs showed significant difference (RR 1.41, 95% CI 1.26-1.59, p<0.0001). Nevertheless, these AEs showing significant difference were mainly associated with MKI toxicities rather than TACE. ConclusionsTACE+MKI combination therapy improved TTP and ORR but not OS and PFS in patients with unresectable HCC. Further high-quality trials are needed to verify these clinical benefits, and our findings could be very informative for future trial design

STABLE SOLUTIONS OF LANE-EMDEN EQUATION

Bachelor'sBACHELOR OF SCIENCE (HONOURS

Model results for Statistical bias correction for CESM-simulated PM2.5

This NC file includes CESM-simulated annual mean aerosol concentrations for 100 years. And the model results are used in paper Statistical bias correction for CESM-simulated PM2.5 (doi: 10.1088/2515-7620/acf917

A Textile Sensor for Long Durations of Human Motion Capture

Human posture and movement analysis is important in the areas of rehabilitation, sports medicine, and virtual training. However, the development of sensors with good accuracy, low cost, light weight, and suitability for long durations of human motion capture is still an ongoing issue. In this paper, a new flexible textile sensor for knee joint movement measurements was developed by using ordinary fabrics and conductive yarns. An electrogoniometer was adopted as a standard reference to calibrate the proposed sensor and validate its accuracy. The knee movements of different daily activities were performed to evaluate the performance of the sensor. The results show that the proposed sensor could be used to monitor knee joint motion in everyday life with acceptable accuracy